MHRA Urges Contraception With GLP-1 Weight-Loss Drugs

Original Article: https://www.medscape.com/viewarticle/mhra-urges-contraception-glp-1-weight-loss-drugs-2025a1000f8o?form=fpf

Regulator Warns: GLP-1 Weight-Loss Drugs and Pregnancy Don’t Mix

The UK’s Medicines and Healthcare products Regulatory Agency (MHRA) has issued a strong warning for women using GLP-1 weight-loss drugs, saying they must use effective birth control at the same time. These drugs, which are becoming more popular for weight loss, as well as for treating type 2 diabetes, could pose risks to a developing baby, though there is not enough research yet to say exactly how dangerous they might be. So far, the MHRA has received over 40 reports of women becoming pregnant while on these medications. The agency says women should not use GLP-1 drugs while pregnant, trying to get pregnant, or breastfeeding, and anyone who becomes pregnant while taking them should stop immediately and talk to a doctor.

Avoid Buying from Unregulated Sources

The MHRA also warned people not to buy these drugs from unregulated sellers like social media accounts or beauty salons. These sources could be unsafe, illegal, and may increase health risks. The only safe way to get GLP-1 medications is through a licensed pharmacy and under a doctor’s care. Community pharmacies have reported a big rise in demand for weight-loss injections, making it more important than ever to follow safety guidelines.

Special Caution for Mounjaro Users

The MHRA gave a specific warning about one drug, Mounjaro (tirzepatide), which may reduce the effectiveness of birth control pills. Women taking Mounjaro should use another form of birth control (like an IUD or implant) for four weeks after starting it and after any dose increase. 

Potential Pregnancy Risks and Gaps in Research

Although there is little research in humans, studies in animals suggest possible risks such as low birthweight and bone problems in babies exposed to GLP-1 drugs during pregnancy. Some human studies have not shown clear harm yet, but doctors agree that more research is needed. Experts are also worried that people buying these drugs online might miss important safety information, including how vomiting or diarrhea—common side effects—can reduce how well birth control pills work, raising the chance of unplanned pregnancy.

Experts Stress Medical Supervision

Doctors and scientists are urging the public to take these medications seriously. They are not just “lifestyle” drugs—they can have serious effects, especially when it comes to reproductive health, and should only be used with proper medical advice.