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Everything Patients Need to Know About Aging on GLP-1s

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Original Article: https://www.medscape.com/viewarticle/everything-patients-need-know-about-aging-glp-1s-2025a1000n72

GLP-1 medications, widely used for weight management and type 2 diabetes, are becoming increasingly popular among adults over 65. In fact, about 8% of older U.S. adults are already taking these drugs. While they offer significant health benefits, age-related changes mean seniors need to understand both the advantages and risks of these medications.

Health Benefits for Seniors

GLP-1s appear to provide multiple benefits beyond weight loss. Large studies show improved heart and kidney health, including lower risk of stroke, better circulation, and fewer hospitalizations for heart failure. Some research even suggests potential protection for the brain, including possible delays in Alzheimer’s and other neurodegenerative conditions. These advantages make GLP-1s a powerful tool for improving quality of life in older adults.

Age-Related Risks

Despite these benefits, older adults face unique challenges. GLP-1s can accelerate muscle loss, leading to weakness and an increased risk of falling. Weight loss may also reduce bone density, making fractures more likely. Low blood pressure and dehydration are additional concerns, especially for seniors already taking medications for heart or kidney conditions.

Tips for Safe Use

Seniors can reduce risks and maximize benefits by focusing on nutrition, exercise, and monitoring their health. If a senior is considering starting a GLP-1, they should discuss the risks as well as the benefits with their doctor. Maintaining a good diet and performing resistance exercises helps protect muscles, while adequate calcium and vitamin D support bone health. Staying hydrated is crucial, especially if appetite decreases. Blood pressure should be monitored closely, and doctors may need to adjust medications as necessary. Regular checkups are also important to track muscle, bone, and overall health, ensuring GLP-1s provide maximum benefit with minimal side effects.

Bottom Line

GLP-1s offer real advantages for older adults, but age makes side effects more significant. Risks like muscle loss, fragile bones, low blood pressure, and dehydration can’t be ignored.