Protein and Exercise Can Maintain Muscle for Individuals taking GLP‑1 Drugs

Original Article: https://www.medscape.com/viewarticle/protein-exercise-can-curb-muscle-loss-related-glp-1-ras-2025a1000yab 

What the Problem is

For people using GLP‑1 receptor agonists (GLP‑1 RAs), which are medications often prescribed for weight loss or diabetes, they can lose not only fat but also significant amounts of muscle. This can negatively affect strength and overall health. Fortunately, new research suggests that combining regular resistance or strength training with sufficient protein intake can help preserve muscle even as weight decreases.

Why This Matters

Muscle is essential for metabolism, blood sugar control, and overall health. Losing too much muscle can reduce strength, lower metabolism, and impact long-term well-being. GLP‑1 medications often suppress appetite, which can lead to inadequate protein intake and further increase the risk of muscle loss.

Recommendations

People on GLP‑1 therapy should pair their treatment with regular exercise, particularly strength training, and ensure they consume enough protein to support muscle maintenance. The medications should be seen as one part of a comprehensive weight-loss plan that includes proper diet and exercise to maintain overall health.

Uncertainties

It is still unclear which individuals are most at risk of losing muscle on GLP‑1 therapy. Older adults and women may be more vulnerable. Additionally, the exact amount of protein and type of exercise needed to fully protect muscle can vary depending on body size, age, and health status, and further research is ongoing.